Collateral Damage from Antigen Receptor Gene Diversification
نویسندگان
چکیده
Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
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عنوان ژورنال:
- Cell
دوره 135 شماره
صفحات -
تاریخ انتشار 2008